The MC1R antibody from MyBioSource.com is a Rabbit Polyclonal antibody to MC1R, Melanocortin 1 Receptor, and SHEP2. This antibody recognizes Human, and Mouse antigen. The MC1R antibody has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer